3-N-Cbz-3-piperidine-propionic acid
3-benzyloxycarbonylamino-3-(3-piperidyl)propanoic acid
CAS: 372144-12-2
Molecular Formula: C16H22N2O4
3-N-Cbz-3-piperidine-propionic acid - Names and Identifiers
| Name | 3-benzyloxycarbonylamino-3-(3-piperidyl)propanoic acid |
| Synonyms | 3-N-Cbz-3-piperidine-propionic acid 3-benzyloxycarbonylamino-3-(3-piperidyl)propanoic acid beta-[[(Phenylmethoxy)carbonyl]amino]-3-piperidinepropanoic acid 3-Piperidinepropanoic acid, .beta.-[[(phenylmethoxy)carbonyl]amino]- |
| CAS | 372144-12-2 |
| InChI | InChI=1/C16H22N2O4/c19-15(20)9-14(13-7-4-8-17-10-13)18-16(21)22-11-12-5-2-1-3-6-12/h1-3,5-6,13-14,17H,4,7-11H2,(H,18,21)(H,19,20) |
3-N-Cbz-3-piperidine-propionic acid - Physico-chemical Properties
| Molecular Formula | C16H22N2O4 |
| Molar Mass | 306.357 |
| Density | 1.200 |
| Boling Point | 524.1°C at 760 mmHg |
| Flash Point | 270.8°C |
| Vapor Presure | 8.23E-12mmHg at 25°C |
| Refractive Index | 1.547 |
3-N-Cbz-3-piperidine-propionic acid - Introduction
-(3-piperidyl)propanoic acid (abbreviated as Cbz-Lys-OH) is an organic compound prepared by the reaction of 3-piperazinylpropanol and Cbz-Lys(BOC)-OH. The following is an introduction to the properties, uses, preparation methods and safety information of the compound:
Nature:
- Cbz-Lys-OH is a colorless crystalline solid.
-Stable at room temperature, but will decompose under high temperature and strong alkali conditions.
-Soluble in alcohol, insoluble in water and non-polar solvents.
Use:
- Cbz-Lys-OH is commonly used as a protecting group in organic synthesis to temporarily protect the Lys (lysine) functional group in amino acids when synthesizing peptides and proteins.
-It can restore the original amino acid through the reaction of deprotecting groups (such as hydrolysis or hydrogen hydrogenation).
Preparation Method:
- Cbz-Lys-OH conventional synthesis method is to react 3-piperazinylpropanol with Cbz-Lys(BOC)-OH in a suitable solvent, usually under basic conditions.
Safety Information:
- Cbz-Lys-OH it is relatively safe to use under routine laboratory conditions, the following matters should be noted:
-Avoid inhalation and skin contact. Wear appropriate personal protective equipment at work, including laboratory gloves and safety glasses.
-Avoid contact with strong oxidants and strong acids during handling and storage.
-Store it in a dry, dark and sealed container, away from fire and flammable materials.
Please note that the above information is for reference only. When using and handling any chemical substances, it is important to follow appropriate safety practices and refer to accurate and reliable chemical safety data sheets.
Nature:
- Cbz-Lys-OH is a colorless crystalline solid.
-Stable at room temperature, but will decompose under high temperature and strong alkali conditions.
-Soluble in alcohol, insoluble in water and non-polar solvents.
Use:
- Cbz-Lys-OH is commonly used as a protecting group in organic synthesis to temporarily protect the Lys (lysine) functional group in amino acids when synthesizing peptides and proteins.
-It can restore the original amino acid through the reaction of deprotecting groups (such as hydrolysis or hydrogen hydrogenation).
Preparation Method:
- Cbz-Lys-OH conventional synthesis method is to react 3-piperazinylpropanol with Cbz-Lys(BOC)-OH in a suitable solvent, usually under basic conditions.
Safety Information:
- Cbz-Lys-OH it is relatively safe to use under routine laboratory conditions, the following matters should be noted:
-Avoid inhalation and skin contact. Wear appropriate personal protective equipment at work, including laboratory gloves and safety glasses.
-Avoid contact with strong oxidants and strong acids during handling and storage.
-Store it in a dry, dark and sealed container, away from fire and flammable materials.
Please note that the above information is for reference only. When using and handling any chemical substances, it is important to follow appropriate safety practices and refer to accurate and reliable chemical safety data sheets.
Last Update：2024-04-09 15:17:57
